De novo lipogenesis following carbohydrate consumption seems to play a big roll in hepatic steatosis risk

“Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption”

Francis WB Sanders, PhD; Animesh Acharjee, PhD; Celia Walker, PhD; Luke Marney, PhD; Lee D Roberts, PhD; Fumiaki Imamura, PhD; Benjamin Jenkins; Jack Case, BA; Sumantra Ray, PhD, MD; Samuel Virtue; Antonio Vidal-Puig; Diana Kuh, PhD; Rebecca Hardy, PhD; Micheal Allison; Nita Forouhi, PhD; Andrew J Murray, PhD; Nick Wareham, PhD, MD; Michele Vacca, MD, PhD; Albert Koulman; Julian L Griffin, DPhil

https://www.repository.cam.ac.uk/handle/1810/277096

Branched-Chain Amino Acids and Type 2 Diabetes Risk

PLoS Med. 2016 Nov 29;13(11):e1002179. doi: 10.1371/journal.pmed.1002179.

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Lotta LA, Scott RA, Sharp SJ, Burgess S, Luan J, Tillin T, Schmidt AF, Imamura F, Stewart ID, Perry JR, Marney L, Koulman A, Karoly ED, Forouhi NG, Sjögren RJ, Näslund E, Zierath JR, Krook A, Savage DB, Griffin JL, Chaturvedi N, Hingorani AD, Khaw KT, Barroso I, McCarthy MI, O’Rahilly S, Wareham NJ, Langenberg C

Direct Link to Paper: http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002179

 

Another step toward universal collaborative methods for metabolomics – Biocrates p180 Kit Ring Trial

Journal:  Analytical Chemistry

Manuscript ID: ac-2016-029307.R1

Title: “Inter-laboratory reproducibility of a targeted metabolomics platform for analysis of human serum and plasma”

Author(s): Siskos, Alexandros; Jain, Pooja ; Römisch-Margl, Werner; Bennett, Mark; Achaintre, David; Asad, Yasmin; Marney, Luke; Richardson, Larissa; Koulman, Albert; Griffin, Julian; Raynaud, Florence; Scalbert, Augustin; Adamski, Jerzy; Prehn, Cornelia; Keun, Hector

Direct Link to Paper: http://pubs.acs.org/doi/pdf/10.1021/acs.analchem.6b02930