2015 – Improving a new feature selection algorithm and incorporating multiple hypothesis correction for comprehensive two-dimensional gas chromatography

Multiple hypothesis correction stems from the single hypothesis testing idea that if I perform a statistical test (e.g. t-test or Fischer ratio) I decide before doing the analysis what level of error, due to random fluctuation, I am willing to accept. This defines the probability that I will be wrong, or falsely report a change in a chemical as significant when I compare its concentration from one sample to another. If I accept a 5% false positive rate, but then measure 1000 chemicals at once, statistically I am saying that I will be wrong 50 times (5% of 1000). Multiple hypothesis correction and modeling the distribution of non-changes lets me improve this false positive rate, so I am not wrong as many times.

Tile-based Fisher ratio analysis of comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS) data using a null distribution approach.

Parsons BA, Marney LC, Siegler WC, Hoggard JC, Wright BW, Synovec RE.

Anal Chem. 2015 Apr 7;87(7):3812-9. doi: 10.1021/ac504472s. Epub 2015 Mar 26.

PMID:
25785933
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