By investigating the metabolite profile of heart tissue from mice that are incapable of regulating fatty acid metabolism, we were able to investigate the changes to metabolism during pressure overload (i.e. a model of hypertension). Turns out that amino acids may play a critical roll in adjusting to metabolic changes in the heart, especially when fat is not available.
Kolwicz SC Jr, Olson DP, Marney LC, Garcia-Menendez L, Synovec RE, Tian R.
Circ Res. 2012 Aug 31;111(6):728-38. doi: 10.1161/CIRCRESAHA.112.268128. Epub 2012 Jun 22.